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论文题目: An mRNA-based vaccine strategy against Zika
作者: Wong G., and Gao G. F.
联系作者:
刊物名称: Cell Res
期:
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年份: 2017
影响因子: 12.393
论文下载: 下载地址
摘要: Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barre syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice.
   

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