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论文题目: Proteolysis of histidine kinase VgrS inhibits its autophosphorylation and promotes osmostress resistance in Xanthomonas campestris
作者: Deng Chao-Ying, Zhang Huan, Wu Yao, Ding Li-Li, Pan Yue, Sun Shu-Tao, Li Ya-Jun, Wang Li, and Qian Wei*.
联系作者:
刊物名称: Nat Commun
期: 1
卷: 9
页: 4791
年份: 2018
影响因子: 13.691
论文下载: 下载地址
摘要: In bacterial cells, histidine kinases (HKs) are receptors that monitor environmental and intracellular stimuli. HKs and their cognate response regulators constitute two-component signalling systems (TCSs) that modulate cellular homeostasis through reversible protein phosphorylation. Here the authors show that the plant pathogen Xanthomonas campestris pv. campestris responds to osmostress conditions by regulating the activity of a HK (VgrS) via irreversible, proteolytic modification. This regulation is mediated by a periplasmic, PDZ-domain-containing protease (Prc) that cleaves the N-terminal sensor region of VgrS. Cleavage of VgrS inhibits its autokinase activity and regulates the ability of the cognate response regulator (VgrR) to bind promoters of downstream genes, thus promoting bacterial adaptation to osmostress.
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