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Name: GAO Bin (Professor)
Title: Deputy Director for CAS Key Laboratory of Pathogenic Microbiology and Immunology; The Director of the Centre for Molecular Immunology.
Dept.: CAS Key Laboratory of Pathogenic Microbiology and Immunology
Tel: +86-10-64807599
Fax:
E-mail: gaob@im.ac.cn
Add.: NO.1 West Beichen Road, Chaoyang District, Beijing 100101, P.R.China
Background:

MSc, The Chinese Academy of Military Medicine, China, 1987
PhD, The University of London, 1990-1993
Post-doc, Oxford University, 1993-1996
Research Leader, Peptide Therapeutics plc, Cambridge, 1996-1997
Research Fellow, Institute of Molecular Medicine, Oxford, 1997-2001
Lecturer, University College London, 2001-2005

Currently, Director of the Center for Molecular Immunology, IMCAS

Editorial board: Journal of Translational Medicine, Infectious Agents and Cancer.


Research interests:

The research in Prof. Gao Bin’s lab is focused on immune responses regulated by interaction between MHC class I molecule and T cell receptor, specifically, the assembly of MHC class I molecules with peptides of invaders, the molecular basis of antigen processing and the involvement of MHC class I-receptors interaction in auto-immune diseases. The lab is also engaged in development of immunotherapy by means of manipulation of MHC-TCR interaction and elucidation of functional-structural basis of immune macromolecules.

Awards & Honors:
 “Distinguished Overseas Chinese Scholar” named by CAS in 2005

Selected Publications and Books:

[1] Changzhen Liu, Thomas S. Walter, Peng Huang, Shiqian Zhang, Xuekai Zhu, Ying Wu, Lucy R. Wedderburn, Peifu Tang, Raymond J. Owens, David I. Stuart, Jingshan Ren, Bin Gao* (2010) Structural and Functional Insights of RANKL-RANK Interaction and Signalling. J Immunol. 184:6910-9.

[2] Zhu X, Wang L, Liu R, Flutter B, Li S, Ding J, Tao H, Liu C, Sun M, Gao B. COMBODY: one-domain antibody multimer with improved avidity. (2010) Immunol Cell Biol. 9 March 2010; doi:10.1038/icb.2010.21.

[3] Changzhen Liu, Hongmei Fu, Barry Flutter, Simon J Powis, Bin Gao* (2010). Suppression of MHC class I surface expression by calreticulin's P-domain in a calreticulin deficient cell line  BBA - Mol Cell Research 1803(5):544-52.

[4] Wu Ying #, Liu Changzhen #, Sun Meiyi, Shen Hexiao, Guo Deyin, Gao Bin *(2010)A Specific Cytotoxic T lymphocyte Epitope Presentation System for Anti-tumor Immunity. Int J Cancer 126: 2373-86.

[5] Fu Hongmei #, Liu Changzhen #, Flutter B, TaoHua, Gao Bin*(2009). Calreticulin maintains the low threshold of peptide required for efficient antigen presentation. Mol Immunol  46(16):3198-206.

[6] Charles Kwok-chong Li, Paul Knopp, Halima Moncrieffe, Bhanu Singh, Sonia Shah, Kanneboyina Nagaraju, Hemlata Varsani, Gao Bin, Lucy R. Wedderburn. (2009). Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis. Am J Pathol. 175(3):1030-40. <IF=5.69>

[7] Vassiliki Sofra, Salah Mansour, Liu Mengya, Gao Bin, Elisavet Primpido, Wang Ping, Li Suling. (2009) Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection.  Eur J Immunol. 39(1):85-95. <IF=4.865>

[8] Chu F, Lou Z, Chen YW, Liu Y, Gao B, Zong L, Khan AH, Bell JI, Rao Z, Gao GF. (2007)  First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape.  J Immunol. 178(2):944-52.

[9] Flutter B, Fu HM, Wedderburn L, Gao B. (2007)  An extra molecule in addition to human tapasin is required for surface expression of beta2m linked HLA-B4402 on murine cell.  Mol Immunol. 44(14):3528-36.

[10]SZ Xu, F Zeng, M Lei, J Li, B Gao, C Xiong, A Sivaprasadarao and DJ Beech  (2005)  Generation of functional ion channel tools by E3-targeting   Nat Biotechnology 23:1289 - 1293 .

[11] Gao B, Williams A, Sewell A, Elliott T. (2004) Generation of a functional, soluble Tapasin protein from an alternatively spliced mRNA Genes & Immunity 5:101-108.

[12] B Gao, Adhikari R, Howarth M, Nakamura K, Gold MC, Hill AB, Knee R, Michalak M, Elliott T (2002). Assembly and antigen-presenting function of
MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 16(1):99-109.

[13] Golgher D, Korangy F, Gao B, Gorski K, Jaffee E, Edidin M, Pardoll DM, 
Elliott T. (2001). An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin. J Immunol 167(1):147-55.

[14] B Gao and MP Esnouf: (1996) Elucidation of the core residues of an epitope using membrane-based combinatorial peptide libraries. J Biol Chem 271:24634-8.

[15] B Gao and Esnouf MP (1996).: Multiple interactive residues of recognition: elucidation of discontinuous epitopes with linear peptides. J Immunol 157:183-8.

Institute Of Microbiology Chinese Academy of Sciences
NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China Phone: 0086-10-64807462 Fax: 0086-10-64807468 Email: office@im.ac.cn