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Name: GUO Hui-Shan
Title: Ph.D, Professor
Dept.: State Key Laboratory of Plant Genomics
Tel: +86-10-64847989
Fax: +86-10-64847989
E-mail: guohs@im.ac.cn
Add.: NO.1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China

2004-present, Principal Investigator; Institute of Microbiology, Chinese Academy of Sciences
2004, joined Institute of Microbiology through the “Hundred Talents” Program of Chinese Academy of Sciences;
1998, joined the National University of Singapore as a Research Fellow and then acting principal investigator;

1998 Postdoctoral Fellow, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Spain

1996, Ph.D., Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Spain

1987, BSc Sun Yat-sen (Zhongshan) University, China

Research interests:

Her research group is mainly interested in molecular mechanism of RNA silencing and dissection of disease resistance in Plant.

Awards & Honors:

2005  “Outstanding Youth Scientist Award (National Science Foundation of China)”

Selected Publications and Books:

Selected Publications and Books:

[1] Cheng-Guo Duan, Chun-Han Wang, Hui-Shan Guo.(2012) Application of RNA silencing to plant disease resistance. Silence. 31.3(1):5. Review.

[2]  Cheng-Guo Duan# , Yuan-Yuan Fang# , Bang-Jun Zhou, Jian-Hua Zhao, Wei-Na Hou, Hui Zhu, Shou-Wei Ding and Hui-Shan Guo*. (2012) Suppression of Arabidopsis ARGONAUTE1-Mediated Slicing, Transgene-Induced RNA Silencing, and DNA Methylation by Distinct Domains of the Cucumber mosaic virus 2b Protein The Plant Cell. 24:259-274.

[3] Bang-Jun Zhou, Pei-Song Jia, Feng Gao and Hui-Shan Guo*. (2012)  Molecular characterization and functional analysis of a necrosis- and ethylene-inducing protein encoding gene family from Verticillium dahlia.  Molecular Plant-Microbe Interactions Vol. 25, No. 7, pp. 964–975.

[4] Ning Xu, Yan Li, Ying-Tao Zhao, Li Guo, Yuan-Yuan Fang, Jian-Hua Zhao, Xiu-Jie Wang, Li Huang and Hui-Shan Guo* (2012) Identification and characterization of small RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus PLoS ONE 7(4):e35036.

[5] Zhu Hui and Guo Hui-Shan*. (2012) The role of virus-derived small interfering RNAs in RNA silencing in plants. Sci China life Sci, 55: 1-7. Review.

[6] Zhonghui Zhang,Hao Chen,Xiahe Huang,Ran Xia,Qingzhen Zhao,Jianbin Lai,Kunling Teng,Yin Li,Liming Liang,Quansheng Du,Xueping Zhou,Huishan Guo,and Qi Xie. (2011). BSCTV C2 Attenuates the Degradation of SAMDC1 to Suppress DNA Methylation-Mediated Gene Silencing in Arabidopsis. The Plant Cell. 23:273-288.

[7] Hui Zhu, Cheng-Guo Duan, Wei-Na Hou, Quan-Sheng Du, Dian-Qiu Lv, Rong-Xiang Fang, and Hui-Shan Guo*. (2011). Satellite RNA-derived satsiR-12 targeting the 3'UTR of Cucumber mosaic virus triggers viral RNAs for degradation. Journal of Virology. 85.13384-13397.

[8] Li Dong, Meng Liu, Yuanyuan Fang, Jianhua Zhao, Xiangfeng He, Xiaobao Ying, Yiyue Zhang, Qi Xie, Namhai Chua, Huishan Guo*. (2011). DRD1-Pol V-dependent self-silencing of an exogenous silencer restricts non-cell-autonomous silencing of an endogenous target gene. The Plant Jouranl. 68:633-645.

[9] Feng Gao§, Bang-Jun Zhou§, Guo-Ying Li, Pei-Song Jia, Hui Li, Yun-Long Zhao, Pan Zhao, Gui-Xian Xia, Hui-Shan Guo* (2010). A Glutamic Acid-Rich Protein Identified in Verticillium dahliae from an Insertional Mutagenesis Affects Microsclerotial Formation and Pathogenicity PLoS ONE 5(12), e15319.

[10] Wei-Na Hou§, Cheng-Guo Duan§, Rong-Xiang Fang, Xiao-Yang Zhou, Hui-Shan Guo* (2011). Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection Molecular Plant Pathology 12(6), 595-605.

[11] Xiao-Bao Ying, Li Dong, Hui Zhu, Cheng-Guo Duan, Quan-Sheng Du, Dian-Qiu Lv, Yuan-Yuan Fang, Juan Antonio Garcia, Rong-Xiang Fang and Hui-Shan Guo*. (2010). RNA-dependent RNA polymerase 1 from Nicotiana tabacum suppresses RNA silencing and enhances viral infection in N. benthamiana. The Plant Cell. 22, 1358-1372.

[12] Kunling Teng , Hao Chen, Jianbin Lai, Zhonghui Zhang, Yuanyuan Fang, Ran Xia, Xueping Zhou, Huishan Guo, Qi Xie* (2010). Involvement of C4 Protein of Beet Severe Curly Top Virus (Family Geminiviridae) in Virus Movement. PLoS one. 5, e11280.

[13]  Lijing Liu, Yiyue Zhang, Sanyuan Tang, Qingzhen Zhao, Zhonghui Zhang, Huawei Zhang, Li Dong, Huishan Guo and Qi Xie*. (2010). An efficient system to detect protein ubiquitination by argoinfiltration in Nicotiana benthamianaThe Plant Journal. 61, 893–903.

[14] Hao Chen, Zhonghui Zhang, Kunling Teng, Jianbin Lai, Yiyue Zhang, Yiliang Huang, Yin Li, Liming Liang, Yiqin Wang, Chengcai Chu, Huishan Guo and Qi Xie*. (2010). Up-regulation of LSB1/GDU3 impacts geminivirus infection by activating the salicylic acid pathway. The Plant Journal. 62, 12-23.

[15]  Weiquan Wang, Yaorong Wu, Yin Li, Jiaying Xie, Zhonghui Zhang, Zhiyong Deng, Yiyue Zhang, Cuiping Yang, Jianbin Lai, Huawei Zhang, Hongyan Bao, Sanyuan Tang,Chengwei Yang, Peng Gao, Guixian Xia, Huishan Guo and Qi Xie*. (2010). A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes. Plant Molecular Biology. 72, 91-99. 

[16] Zheng Nuoyan, Xia Ran, Yang Cuiping, Yin Bojiao, Li Yin, Duan Chengguo, Liang, Liming, Guo Huishan and Xie Qi*. (2009) Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice. Vaccine. 27:5001–5007.

[17]  Cheng-Guo Duan, Chun-Han Wang, Rong-Xiang Fang and Hui-Shan Guo*. (2008). Artificial microRNAs highly accessible to targets confer efficient virus resistance in plants. Journal of Virology. 82:11084-11095.

[18] Xiang-Feng He, Yuan-Yuan Fang, Lei Feng and Hui-Shan Guo*. (2008). Characterization of conserved and novel microRNAs and their targets, including a TuMV-induced TIR-NBS-LRR class R gene-derived novel miRNA in Brassica. FEBS letter. 582:2445-2452.

[19]  Cheng-Guo Duan, Chun-Han Wang and Hui-Shan Guo*. (2008). Delayed resistance to Cucumber Mosaic Virus mediated by 3’UTR derived hairpin RNA. Chinese Science Bulletin. 53:3301-3310.

[20] Jianbin Lai, Hao Chen, Kunling Teng, Qingzhen Zhao, Zhonghui Zhan, Yin Li, Liming Liang, Ran Xia, Yaorong Wu, Huishan Guo and Qi Xie*. (2008). RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle. The Plant Journal. 57, 905-917.

[21]  Zhong-Hui Zhang, Qi Xie and Hui-Shan Guo*. (2007). Antiviral Defense in Plants. Plant Viruses Global Science Books. Invited mini-review 1, 21-26.

[22] Quan-Sheng Du, Cheng-Guo Duan, Zhong-Hui Zhang, Yuan-Yuan Fang, Rong-Xiang Fang, Qi Xie, and Hui-Shan Guo*. (2007). DCL4 targets Cucumber mosaic virus satellite RNA at novel secondary structures. Journal of Virology. 81:9142-9151.

[23] Yiyue Zhang, Chengwei Yang, Yin Li, Nuoyan Zheng, Hao Chen, Qingzhen Zhao, Ting Gao, Huishan Guo, and Qi Xie*. (2007). SDIR1 Is a RING Finger E3 Ligase That Positively Regulates Stress-Reponsive Abscicic Acid Signaling in Arabidopsis. The Plant Cell. 19:1912-1929.

[24] Qi Xie and Hui-Shan Guo*. (2006). Systemic antiviral silencing in plants. Virus research. 118:1-6 (Review).

[25]  Cheng-Guo Duan, Chun-Han Wang and Hui-Shan Guo*. (2006). Regulation of MicroRNA on plant development and viral infection. Chinese Science Bulletin. 51:269-278 (Review).

[26] Hui-Shan Guo, Qi Xie, Ji-Feng Fei and Nam-Hai Chua. (2005). microRNA directs mRNA cleagage of the transcription factor NAC1 to desensitize auxin signals for Arabidopsis lateral root development. The Plant Cell. 17:1376-1386.

[27] Hui-Shan Guo, Jifeng Fei, Qi Xie and Nam-Hai Chua. (2003). A chemical-regulated inducible RNAi system in plants. The Plant Journal. 34:383-392.

[28] Carmen Simon-Mateo, Juan Jose Lopez-Maya, Hui-Shan Guo, Elena Gonzalez and Juan Antonio Garcia. (2003). Suppressor activity of potyviral and cucumoviral infections in potyvirus-induced transgene silencing. Journal of General Virology. 84:2877-2883.

[29]  Qi Xie, Hui-Shan Guo, Geza Dallman, Shengyun Feng, Allan M. Weissman and Nam-Hai Chua. (2002). SINAT5, aRING E3 ubiquitin protein ligase, promotes post-translational degradation of NAC1 to attenuate auxin signals. Nature. 419:167-170.

[30] Hui-Shan Guo and Shou-Wei Ding. (2002). A viral protein inhibits the long range signaling activity of the gene silencing signal. The EMBO Journal. 21:398-407.

[31]  P.Lucy*, Hui-Shan Guo*, Wan-Xiang and Shou-Wei Ding. (2000). Suppression of post-transcriptional gene silencing by a plant virual protein localized in the nucleus. The EMBO Journal. 19:1672-1680. * contributed equally to this work *

[32] Hong-Wei Li, Andrew P.Lucy, Hui-Shan Guo , Wan-Xiang Li, Liang-Hui Ji, Sek-Man Wong and Shou-Wei Ding. (1999). Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism. The EMBO Journal. 18:2683-2691.

[33]  Hui-Shan Guo, Juan Jose Lopez-Moya and Juan Antonio García. (1999). Mitotic stability of infection-induced resistance to plum pox potyvirus associated with transgene silencing and DNA methylation. Mol. Plant-Microbe Interact. 12:103-111.

[34] Hui-Shan Guo, Juan Jose Lopez-Moya, Juan Antonio García. (1998). Susceptibility to recombination rearrangements of a chimeric plum pox potyvirus genome after insertion of a foreign gene. Virus Research. 57:183-195.

[35] Hui-Shan Guo, Maria Teresa cervera and Juan Antonio García. (1998). Plum pox potyvirus resistance associated to transgene silencing that can be stabilized after different number of plant generations. Gene. 206:263-272.

[36] Andrés Fernández, Hui-Shan Guo , Pilar Sáenz, Laureano Simón, Gomez de Cedron M. and Juan Antonio García. (1997). The motif V of plum pox potyvirus CI RNA helicase is involved in NTP hydrolysis and is essential for virus RNA replication. Nucleic Acids Research. 15:4474-80.

[37]  Laureano Simón, Hui-Shan Guo and Juan Antonio García. (1997). Cap-indeperdent leaky scanning as the mechanism of translation initiation of a plant viral genomic RNA. Journal of General Virology. 78:2691-2699.

[38] Laureano Simón, Hui-Shan Guo and Juan Antonio García. (1997). Long sequences in the 5' noncoding region of plum pox virus are not necessary for viral infectivity but contribute to viral competitiveness and pathogenesis. Virology. 233:157-162.

[39] Hui-Shan Guo and Juan Antonio García. (1997). Delayed resistance to plum poxpotyvirus mediated by a mutated RNA replicase gene: Involvement of a gene-silencing mechanism. Mol. Plant-Microbe Interact. 10:160-170.

Institute Of Microbiology Chinese Academy of Sciences
NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China Phone: 0086-10-64807462 Fax: 0086-10-64807468 Email: office@im.ac.cn