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Name: ZHOU Xuyu
Title: Professor
Dept.: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Treg Research Group
Tel: +86-10-64806075
E-mail: zhouxy@im.ac.cn
Add.: 10th West Beisihuan Road, Haidian District, Beijing 100080, P.R.China

Prof. Zhou graduated from Shandong University in 1993 and received his Ph.D degree from Osaka University, Japan in 2001. From 2003 to 2009, he was trained as a postdoctoral at University of California, San Francisco. In the fall of 2009, Dr. Zhou joined the Institute of Microbiology as a professor supported by “one hundred talents program” of Chinese Academy of Sciences.

Research interests:

The Treg Research Group focuses on understanding the immune regulation of regulatory T cells (Treg). Treg are a specialized CD4+ T cell lineage that plays a central role in the preservation of self-tolerance and whose dysfunction has been implicated in autoimmune. Research in our laboratory is aimed at decipher the mechanism of Treg suppression and their identity control. We found that the essential role for microRNA-dependent regulation of gene expression in the maintenance of Treg-cell-specific deletion of dicer developed a spontaneous, aggressive autoimmune disease that was indistinguishable from that observed in mice that lack Foxp3 or Treg cells. One of major research goals in our laboratory are extending our previous work and determining the individual microRNAs and microRNA targets that are important in maintaining Treg identity. More recently, we have demonstrated the instability of the transcription factor Foxp3 invivo, now we are investigating the molecular basis underlying their functional stability.

Awards & Honors:

Selected Publications and Books:

[1] Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009 Sep;10(9):1000-7. Epub 2009 Jul 26.

[2] Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA. Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol. 2009 Jun;21(3):281-5. Epub 2009 Jun 6. Review.

[3] Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 1;205(9):1983-91. Epub 2008 Aug 25.

[4] Zhou XY, Yashiro-Ohtani Y, Toyo-Oka K, Park CS, Tai XG, Hamaoka T, Fujiwara H. CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4+CD8+ thymocytes and supports their differentiation to the CD4 lineage. J Immunol. 2000;164:1260-8.

[5] Zhou XY, Yashiro-Ohtani Y, Nakahira M, Park WR, Abe R, Hamaoka T, Naramura M, Gu H, Fujiwara H. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. J Immunol. 2002;168:3847-54.

Google Scholar : http://scholar.google.com/citations?hl=en&user=WYLyCTAAAAAJ

Institute Of Microbiology Chinese Academy of Sciences
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