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Name: FANG Min
Title: PhD, Professor
Dept.: CAS Key Laboratory of Pathogenic Microbiology and Immunology
Tel: +86-10-64806065
E-mail: fangm@im.ac.cn
Add.: 1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China

Dr. Fang graduated from Lanzhou University in 1994 and received her Ph.D from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2003. She got her postdoctoral training at Fox Chase Cancer Center from 2003 to 2008. She worked as a research associate and then as a staff scientist at Fox Chase Cancer Center from 2008 to 2012. She joined the Institute of Microbiology, CAS as a professor supported by “Thousand Young Talents Program” of the China’s government in 2012.

Research interests:

The current research in our laboratory mainly focuses on understanding the role of Natural Killer (NK) cells in infectious diseases and cancers, especially the role of age-dependent defect of NK cells in regulating increased susceptibility to viral infections and cancer carcinogenesis.

Awards & Honors:

Selected Publications and Books:

[1] Fang M, Siciliano N, Hersperger A, Roscoe F, Hu A, Ma X, Shamsedeen A, Eisenlohr L and Sigal L. Perforin-dependent CD4+ T cell cytotoxicity contributes to control a murine poxvirus infection. Proc Natl Acad Sci U S A. 2012; 109(25):9983-8.
[2] Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL and Sigal LJ. CD94 is essential for NK cell-mediated resistance to a lethal viral disease. Immunity. 2011, 34(4):579-89.
[3] Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL. Development and function of CD94-deficient natural killer cells. PLoS One. 2010, 5(12):e15184.
[4] Fang M, Roscoe F, Sigal LJ. Age-dependent susceptibility to a viral disease due to decreased NK cell numbers and trafficking. J Exp Med. 2010, 207(11):2369-81.
[5] Fang M and Sigal L. Studying NK cell responses to Ectromelia virus infections in mice. Methods Mol Biol. 2010, 612:411-28.
[6] MacFarlane AW, Yamazaki T, Fang M, Sigal LJ, Kurosaki T, Campbell KS.  Enhanced NK-cell development and function in BCAP-deficient mice.  Blood. 2008, 112:131-140.
[7] Fang M, Lanier LL, Sigal LJ. A Role for NKG2D in NK Cell-Mediated Resistance to Poxvirus Disease. PLoS Pathog. 2008, 4(2):e30.
[8] Xu RH*, Fang M*, Klein-Szanto A, Sigal LJ. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci U S A. 2007, 104(26):10992-7. (* Co-first author)
[9] Fang M, Sigal LJ. Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host. J Immunol. 2006, 177(11):8027-36.
[10] Fang M, Cheng H, Dai Z, Bu Z, Sigal LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. Virology. 2006, 345(1):231-43.
[11] Fang M, Sigal LJ. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol. 2005, 175(10): 6829-36.
[12] Fang M, Zhao R, Yang Z, Zhang Z, Li H, Zhang XT, Lin Q, Huang HL. Characterization of an anti-human ovarian carcinoma×anti-human CD3 bispecific single-chain antibody with an albumin-original interlinker. Gynecol Oncol. 2004, 92:135-146.

Institute Of Microbiology Chinese Academy of Sciences
NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China Phone: 0086-10-64807462 Fax: 0086-10-64807468 Email: office@im.ac.cn